Ronald Koeman's Everton side will be looking to get back on track following their poor performance in the Merseyside derby on the weekend.
The Toffees haven't beaten any of the teams in the top six away from home this season so it's likely to be a very tough game at Old Trafford on Tuesday night.
Robles is likely to remain in goal for Everton, as the Everton stopper looks to put his side's poor defensive performance against Liverpool behind him.
Despite losing against Liverpool on Saturday, it was a very special day for young Matthew Pennington as he scored at the Kop end in his first ever Premier League appearance for Everton.
Williams and Jagielka will certainly have their hands full on Tuesday as Ibrahimovic is set to return and both defenders will have to demonstrate all their experience in order to stop the Swede.
Former Red Devil Morgan Schneiderlin is set to miss out on his return to Old Trafford as he is still recovering from a calf strain.
Despite not starting in the Merseyside derby, Ronald Koeman might opt to play the experienced Gareth Barry in the middle of the park to provide extra protection to the back four.
Both Romelu Lukaku and Ross Barkley have to step up to the plate and perform on the big stage.
Lukaku was fairly anonymous in the Merseyside derby whereas Barkley was very lucky not to have picked up a red card following two reckless challenges.
Enner Valencia is likely to support them up front.