Mauricio Pochettino will be looking to cement Tottenham's place in the top four and will hope to increase their lead over third place Manchester City with victory at Turf Moor.
After the international break, Spurs will be desperate to extend their winning run to four successive Premier League games. Here's the team he could pick.
Hugo Lloris is Pochettino's first choice goalkeeper and will resume that position on Saturday.
Ben Davies and Kyle Walker could play as wing-backs leaving Eric Dier, Jan Vertonghen and Toby Alderweireld as Spurs' back three on Saturday.
Kyle Walker played well against Germany during the international break at right wing back which will give encouragement to Pochettino.
Tottenham have only conceded 21 goals in 28 Premier League games this season, which is the joint best defence in the league with leaders Chelsea.
Victor Wanyama and Moussa Dembele could play deeper in the middle of the park allowing Christian Eriksen to push further forward and link up with Dele Alli at the creative heart of the Spurs team.
Argentina star Erik Lamela remains unavailable due to the hip injury that has kept him out of action since October.
Harry Kane and Erik Lamela remain sidelined for Spurs, with Vincent Janssen unlikely to feature after withdrawing from the Netherlands squad over the international break due to illness.
Son Heung-Min will lead the attack due to Janssen's illness and Kane's ankle injury which will keep him out of action for a few more weeks. Alli could feature just behind Son.
Spurs have the second deadliest attack in the league, scoring 55 goals so far, four behind Chelsea's 59.