Pep Guardiola's side will be facing Sporting Lisbon in the last-16, and are being tipped to go all the way to the final to land a long-awaited Champions League title.
Bayern are being tipped to get the better of RB Salzburg, while Ajax are predicted to get the better of Benfica. However, according to the supercomputer, Real Madrid are in for a rude shock and have been tipped to be knocked out of the tournament by Paris Saint-Germain.
A spokesperson handling the supercomputer simulation said: "The Champions League last 16 draw has been made - at the second attempt - and most of the favourites will progress according to our supercomputer. Real Madrid will feel the most aggrieved having originally been drawn against Benfica, but now faced with huge-spending PSG.
"And as the tournament reaches its latter stages, City are the side backed to go all the way and lift the trophy come May."
Meanwhile, Michael Owen and Rio Ferdinand both predicted only Bayern could challenge City, Chelsea, and Liverpool in the Champions League this season. "The Spanish teams aren’t the force of old," said Owen. "I've said lots of times I can’t have Paris Saint-Germain go and win. For me, it’s Bayern Munich or an English team."
Ferdinand added: "I don’t see past the three English teams [not including Man Utd] to be fair. I think the three English teams will win it this year.
"Bayern might stake a claim but the English teams just look so powerful, tactically they’re on it, the individuals, they’ve got three of the best managers as well. When you get to the latter stages where you need people to organise your team well, the experienced teams all know how to win this tournament."