The two sides are considered to be arch-rivals, and it will be an interesting start to the new league season, which will be played behind closed doors at three venues in Goa.
Both ATKMB and KBFC will be looking to kick-start their new campaign in style, with a win over their arch-rivals in the inaugural game.
Both teams appear to have assembled a strong squad, one that is capable of fighting for the title, but it remains to be seen how that translates to performances on the pitch.
It is also worth noticing that the opening game has many sub-plots, not least the fact that Sandesh Jhingan is going to face Kerala Blasters, a club he spent six seasons.
Elsewhere, Blasters' coach Kibu Vicuna became a known name in the Indian football arena by guiding Mohun Bagan to I-League title last season. Mohun Bagan have since merged with ATK and became ATK Mohun Bagan. So, in a way, Kibu Vicuna will be up against his former side.
Head to Head Stats
Matches - 14
Matches ATKMB Won - 5
Matches KBFC Won - 4
Draws - 5
Kerala Blasters: Albino Gomes, Jessel Carneiro, Bakary Kone, Costa Nhamoinesu, Nishu Kumar, Vicente Gomez, Jeakson Singh, Sahal Abdul Samad, Facundo Pereyra, Rahul KP, Gary Hooper
ATK Mohun Bagan: Arindam Bhattacharya, Prabir Das, Sandesh Jhingan, Tiri, Pritam Kotal, Pranoy Halder, Carl McHugh, Javi Hernandez, Subhasish Bose, David Williams, Roy Krishna