Liverpool and Manchester United both have tricky games, and players like Diogo Jota, Paul Pogba, and Trent Alexander-Arnold could find themselves being removed from teams in favour of players who have easier fixtures.
Here are four players to pick for your FPL team for gameweek 7.
Edouard Mendy - £6.0 - vs Southampton
Mendy looks like a good bet to keep a clean sheet this weekend. Southampton have blanked in their last three matches, while the Chelsea shot-stopper has kept three clean sheets in five games so far. With Alisson and Ederson facing each other, and Hugo Lloris playing behind an increasingly leaky Spurs defence, Mendy is a solid goalkeeper this gameweek.
Raphinha - £6.5 - vs Watford
Raphinha rewarded managers who stuck with him last week, recovering from injury, and scoring Leeds' only goal of the game. He was unlucky not to score more, but will be the main source of goals in Patrick Bamford's absence.
Michail Antonio - £7.9 - vs Brentford
Antonio is currently the joint top-scorer with five goals despite being sent off in one game and missing another due to suspension. The Hammers' hitman is also joint-top for shots (25) and second for big chances (seven), and will be expected to continue his fine form against Brentford this weekend.
Romelu Lukaku - £11.7m - vs Southampton
Although Lukaku failed to score against Liverpool, Tottenham, and Manchester City, the Belgium has fared well against non-top six opponents. Against a Saints' side who are yet to win a league game this season, Lukaku has a strong chance to find the back of the net.