This will be the first time the two clubs face-off in Europe's premier competition and consist of world class players capable of changing the game in a second. Here, we take a look at five players who will have a major bearing on the result for their respective sides.
No PSG game can be written about without mentioning their star name in Neymar, with the Brazilian their biggest superstars and matchwinner on the pitch. The 29-year-old has been integral in their Champions League run, scoring three times and assisting once in the last three games.
Likewise, it seems that he enjoys playing against English teams, since he has participated in nine goals in the 12 games he has played against British clubs.
2. Kevin De Bruyne
If PSG have Neymar, then City have Kevin De Bruyne - with the Belgian widely considered as the best midfielder in the world. The 29-year-old is key to everything his side does in attack, and has participated in eight goals in his last seven games in the knockout stages of the Champions League - four goals and four assists.
3. Kylian Mbappe
Kylian Mbappe enhances his standing in world football with every game he plays and he has been in brilliant form for PSG in the competition and deadly when it comes to the knockout stages.
The youngster scored a hat-trick against Barcelona at the Camp Nou and one more goal in the second leg of the round of 16 from the spot. He scored another two against Bayern Munich which means that six of his last eight goals in the Champions League have come in the knockout rounds.
4. Ruben Dias
Ruben Dias completely transformed City's defence on his arrival in the summer and he has continued in the same vein throughout the season so far. He has arguably been the signing of the season and how he deals with the likes of Neymar and Mbappe will determine the fate of the tie.
PSG breathed a sigh of relief on hearing that their key defender and skipper, Marquinhos was passed fit to play in the game after sitting out the quarter-final second leg with an adductor injury. The Brazilian has established himself as one of the best defenders in the world and his presence will not only help defensively but also provide morale on the pitch.