Reigning champions Bayern have a three-goal cushion while City have a two-goal advantage. Both clubs have an easy task in their second leg tie while Real Madrid and Chelsea only have a one-goal lead and face a tough test against Atalanta and Atletico Madrid respectively.
No team from Spain or Italy has qualified for the quarter-finals as of now, so Madrid, Atalanta and Atletico need a win here, so the match between Los Blancos and La Dea should make for an interesting watch.
Here is our preview of the Round of 16 action in the Champions League for the week.
1. Real Madrid vs Atalanta
One of the two last 16 fixtures kicking off tomorrow night is Real Madrid vs Atalanta. The hosts are leading 1-0 on aggregate, with Ferland Mendy scoring a crucial away game in the 86th minute of the first leg tie.
Madrid have played two 1-1 draws since the first leg game but returned to winning ways with a 2-1 win over Elche last time around. Atalanta returned to their goalscoring ways and in the four games since the first leg have scored 10 goals and have three wins to their name.
In terms of form, the visitors look the favourites to record a win in this fixture but Real Madrid have a lot of experience in big games like this one and could very well hold onto their one-goal lead.
Eden Hazard will miss the game on account of a muscle injury while Remo Freuler is suspended for this game after picking up a straight red card in the first leg.
Real Madrid's probable lineup (4-3-3):Thibaut Courtois (GK); Lucas Vazquez, Raphael Varane, Sergio Ramos, Ferland Mendy; Luka Modric, Federico Valverde, Toni Kroos; Marco Asensio, Karim Benzema, Vinícius Júnior.
Atalanta's probable lineup (3-4-1-2): Pierluigi Gollini (GK); Rafael Toloi, Cristian Romero, Jose Luis Palomino; Joakim Maehle, Marten de Roon, Mario Pasalic, Robin Gosens; Ruslan Malinovskyi; Luis Muriel, Duvan Zapata.
Prediction: 2-1 win for Real Madrid.
2. Manchester City vs Borussia Monchengladbach
In tomorrow's second game Manchester City host Borussia Monchengladbach at the Etihad Stadium. The Cityzens suffered their first loss in 21 games against city rivals Manchester United last week but have bounced back well and recorded two resounding wins since.
This will be the third game for City in seven days, so we can expect Pep Guardiola to make some changes to the squad for the game, as his side have already scored two away goals in this two-legged fixture.
Die Fohlen have lost all of their last four games since the first leg and the odds of them overturning a two-goal deficit are looking very bleak. Christoph Kramer is a doubt for the visitors while City also have a clean bill of health apart from Nathan Ake.
Manchester City's Probable Lineup (4-2-3-1): Ederson Moraes (GK); Kyle Walker, Ruben Dias, Aymeric Laporte, Oleksandr Zinchenko; Fernandinho, Ilkay Gundogan; Riyad Mahrez, Kevin De Bruyne, Raheem Sterling; Sergio Aguero
Borussia Monchengladbach's Probable Lineup (4-3-3): Yann Sommer (GK); Stefan Lainer, Matthias Ginter, Nico Elvedi, Oscar Wendt; Denis Zakaria, Florian Neuhaus, Breel Embolo; Lars Stindl, Marcus Thuram, Alassane Plea
Prediction: 2-1 win for Manchester City.
3. Bayern Munich vs Lazio
The reigning champions welcome Lazio to the Allianz Arena in the second leg tie of their Round of 16 fixture. Bayern Munich already have a foot in the quarter-final having scored four crucial away goals in the first leg.
We expect Hansi Flick to make a few changes to the squad that started in the 3-1 win over Werder Bremen, firstly, because they have a three-goal cushion and secondly because they play Stuttgart in the Bundesliga just two days later.
The hosts have won all three of their games since the first leg while Lazio have lost two and recorded just one win in the same period. Manuel Lazzari is sidelined for the visitors for the game while David Alaba is also doubtful and might miss this second leg-tie.
Bayern Munich's Probable Lineup (4-2-3-1): Manuel Neuer (GK); Alphonso Davies, Niklas Sule, Jerome Boateng, Benjamin Pavard; Leon Goretzka, Joshua Kimmich; Kingsley Coman, Thomas Muller, Leroy Sane; Robert Lewandowski
Lazio's Probable Lineup (3-5-2): Pepe Reina (GK); Franco Acerbi, Wesley Hoedt, Adam Marusic; Mohamed Fares, Luis Alberto, Lucas, Sergej Milinkovic-Savic, Senad Lulic; Ciro Immobile, Joaquin Correa
Prediction: 3-1 win for Bayern Munich.
4. Chelsea vs Atletico Madrid
The last game of the Round of 16 in the Champions League is also one of the games to look forward to this week. Chelsea have looked like a rejuvenated side under new manager Thomas Tuchel and are yet to suffer a single defeat under the former Paris Saint-Germain manager.
Atletico Madrid have conceded just 18 goals in La Liga this season, only Lille have a better defensive record across Europe's top five leagues. The Blues also have 10 clean sheets from their last 12 fixtures, so this fixture is poised to be a closely contested game.
Olivier Giroud scored a stunner in the first leg to give Chelsea a crucial away goal, which put the pressure on Diego Simeone's men to become the first side to score two goals against The Blues in over two months.
The hosts will be without Jorginho and Mason Mount on account of the accumulation of yellow cards while Atletico Madrid have no injury or suspension concerns at the moment.
Chelsea's Probable lineup (3-4-2-1):Edouard Mendy; Cesar Azpilicueta, Thiago Silva, Antonio Rudiger; Reece James, Mateo Kovacic, N'Golo Kante, Marcos Alonso; Kai Havertz, Hakim Ziyech; Olivier Giroud
Atletico Madrid's Probable Lineup (4-1-41):Jan Oblak; Kieran Trippier, Raul Jimenez, Stefan Savic, Renan Lodi; Koke, Marcos Llorente, Saul Niguez; Joao Felix, Yannick Carrasco; Luis Suarez
Prediction: 1-1 draw.