The two teams share a long-standing rivalry, but this was the first time the cross-town rivals met each other in the Indian Super League.
It proved to be an entertaining and thrilling contest, won by ATKMB, who put two past the Red and Gold Brigade to register their second consecutive victory in the seventh edition of ISL.
For East Bengal, it was not the result they would have hoped for in their ISL debut, but they had plenty of things to be encouraged of from the match.
It was East Bengal who dominated the possession on the night and started the match on the front foot. Robbie Fowler's side had an early opportunity in the 8th minute, but Anthony Pilkington could not make the most after he had received a pass inside the box.
12 minutes later, the Red and Gold Brigade had their first shot on target, but Arindam Bhattacharya comfortably saved Pilkington's shot from distance.
ATKMB had their first shot on goal in the 35th minute. After receiving the ball from a Subhasish Bose throw-in, Javi Hernandez took two touches to create space and then volleyed the ball, but Debjit Majumder saved it away for a corner.
The deadlock was yet to be broken when the referee blew the half-time whistle, but ATKMB opened the cards just four minutes into the second half. Roy Krishna, who scored their winner against Kerala Blasters in the opening match, shot from the edge of the box and beat Majumder to score the first of the night.
SCEB, who continued their dominance on the ball, pushed for an equaliser and created opportunities but failed to find the back of the net. Jacques Maghoma's shot flew over the bar in the 63rd minute, while Bhattacharya made a brilliant save to deny Pilkington's curling-effort.
Two minutes later, ATKMB doubled their lead and put the game to bed. Prabir Das played a lofted ball to Manvir Singh, who after escaping an SCEB tackle, raced on and cut into the box and triggered a powerful shot into the top corner to seal ATKMB's victory in ISL's first ever Kolkata Derby.