Manchester United start their most physically exhausting period with the trip to Southampton. Jose Mourinho's side will be on the road for six of their next seven games away which would most certainly test the depth of their squad.
The Red Devils have won on nine occasions in their last 12 visits to St. Mary's and would be hoping to extend that run. Anthony Martial and Marcus Rashford are in fine form, and looking at the tough trip to Moscow, Mourinho could make some changes.
Paul Pogba (hamstring) and Marcos Rojo (knee) are out of the tie, but the rest of the squad, including Luke Shaw, is fit and raring to go. As for Southampton, Virgil van Dijk could make his first start since January. This would certainly give the Saints manager,