The clarion calls for Arsene Wenger's head are back again, and many Gunners' fans will see this match as an opportunity to put further pressure on the beleaguered Frenchman.
However, Arsenal were impressive away against Chelsea on Sunday, earning a point in a fixture in which they had lost the previous 5. Wenger will use the Carabao Cup as an opportunity for his younger talents, but a number of Arsenal's first team players will also need to prove they're up for the fight...
Ospina was consistently linked with a move to Turkish giant Fenerbahce last season after finding his first team opportunities limited. However, with Petr Cech in the autumn of his career at 35, this is a rare opportunity for the Colombian to stake his claim as the Gunners' future number 1.
21-year-old Rob Holding is tipped to start on the right of the three, with Per Mertersacker, (who announced he will retire at the end of the season and run Arsenal's academy) in the middle.
They're likely to partner either Monreal or Calum Chambers in a three-man defense with Laurent Koscielny and Shkodran Mustafi rested.
Jack Wilshere's quest for an extended period of match fitness goes on, after his brief run-out in Arsenal's 3-1 against Cologne in the Europa League last week. He will likely start alongside Egypt international Mohamed Elneny in the centre of the park.
Youngster Reiss Nelson is set to start as right wing-back with either Kolasinac or Ainsley Maitland-Niles at left wing-back.
After inexplicably starting on the bench against Chelsea to the fury of many Arsenal fans, Sanchez is likely to get a run out against the League One side.
Giroud's 5 league appearances this season have all come as a sub and the Frenchman will need a strong performance to oust rested compatriot Alexandre Lacazette permanently.
Walcott is also struggling for first-team opportunities, and is auditioning for his place here, making just two appearances as a sub in the league so far.