As the two clubs prepare to face each other for the first time we look at where on the pitch the match could be won or lost.
With Hoffenheim preparing to make their first European appearance, they will be hoping for a result in the first leg over the five time Champions league winners, who have a reputation for performing on European nights.
3. Set Pieces
Liverpool's Achilles heel. Set pieces were the reason Liverpool didn't leave Vicarage Road with three points. Facing off against Hoffenheim won't be any easier, as the German side scored the most set-pieces out of anyone in the Bundesliga last season.
Should Klopp continue to deploy the zonal system to defend set pieces, Liverpool could be found out once more. With the height of Kevin Vogt at the back, don't be surprised if the centre back finds himself on the score-sheet on Tuesday night.
2. Liverpool Front Three vs Hoffenheim Back Three
Roberto Firmino will be back to haunt Hoffenheim, who will know all about the Brazilian who spent four years at the club. His role in the side will see Klopp get the best out of his talent out wide, with Sadio Mane and Mohamed Salah both possessing lightning pace and lethal finishing.
Hoffenheim boss Julian Nagelsmann deploys three at the back, and his centre backs will have the task of dealing with the multiple angles of attack that the front three brings. With pace and creativity in abundance, to deal with these threats will be a huge challenge.
1. Andrej Kramaric vs Dejan Lovren and Joel Matip
Hoffenheim's star man Andrej Kramaric will face off against a centre-back pairing that was statistically Liverpool's most successful last season, but doubt remains as Liverpool conceded three goals on Saturday. Meanwhile, Kramaric came off the back of an excellent goal-scoring season for Hoffenheim.
Scoring 18 goals in all competitions, but also providing a further eight assists, showing how crucial the Croatian is to the attack. Facing off against his compatriot Dejan Lovren, Kramaric will be hoping to capitalise on the error-prone defender, to score Hoffenheim's first European goal in their history.