Pep Guardiola's side have broken numerous records throughout their impressive season to date, and another record could be rewritten on Sunday with a victory as the last time the Citizens won at Anfield in the Premier League was in 2003.
Here's the City side who could re-write history on Sunday.
No questions need to be asked, if Ederson is fit he plays. He is fit, so he plays.
Guardiola has had to contend with a number of defensive changes throughout the season following injuries to Vincent Kompany and Benjamin Mendy, but the City boss is expected to start the same back-line as that won against Watford last time out.
However, he could be tempted to offer Danilo a starting berth ahead of Fabian Delph to help combat the pace Liverpool posses throughout their front three.
- de Bruyne17
A formidable midfield three which seemingly has it all, Kevin de Bruyne will once again prove vital in pulling the strings for City on Sunday, while Fernandinho will provide a vital line of cover in defence to stop the Reds exploiting any space.
Although David Silva has had an emotional few weeks due to events in his personal life, he is expected to start and his magic touch and ability is likely to cause Liverpool a plethora of problems.
- Leroy Sane19
The long-term injury to Gabriel Jesus ensures Sergio Aguero is handed yet another start as the leading man in City's attack.
Raheem Sterling is set to return to his former stomping ground in the best form of his career, having scored 18 goals in 25 appearances this season.
Leroy Sane will support the attack and his direct play against Joe Gomez will be crucial in stopping the Liverpool right-back from steaming forward.