Virgil van Dijk has become the latest name from Southampton to make a big money move to Premier League rival. Liverpool announced they had reached an agreement with van Dijk to sign to centre-back for a record-shattering £75m.
He becomes the sixth player in recent seasons to make the move from St. Mary's to Merseyside, while Southampton fans by now must be used to feeling of losing another one of their star players.
Since the club's promotion back to the Premier League, they have watched stars come and go, giving the Saints a reputation of being a 'selling' club.
But how do Southampton's former players fare once they move away from the South coast?
Here's a ranking of nine of Southampton's most recent high profile departures on their success at their new clubs.
9. Dejan Lovren to Liverpool (2014)
Transfer fee: £20m
Dejan Lovren was only at Southampton for one season before he was snatched up by Liverpool for £20m in the summer of 2014, and the Croatian became the most expensive defender in Liverpool's history.
Since then, Lovren has become the lightning rod for complaints about Liverpool's sub-standard defending over the past few seasons, and he has consistently been named as one of the worst transfers in Liverpool's history for his high price tag and his inconsistent performances.
After three and a half seasons at Anfield, he could well see his first team opportunities diminish following the arrival of Van Dijk.
8. Rickie Lambert to Liverpool (2014)
Transfer fee: £4m
You can't blame Rickie Lambert too much for deciding to leave Southampton after five years of solid service. At the age of 32, Lambert knew he would never get another chance to move to big English club, especially his beloved boyhood club Liverpool.
At £4m, it was not too big of a risk for the Reds to take on an ageing Lambert, but the experiment ultimately failed to deliver.
Lambert lasted one season at the Reds where he managed to score just three goals in all competitions.
7. Luke Shaw to Man Utd (2014)
Transfer fee: £27m
For a time, Luke Shaw was the golden boy of Southampton's latest crop of exciting young talent. In his final season with the Saints, he was shortlisted for the PFA Young Player of the Year, and he was selected for the PFA Team of the Year.
Shaw made his move to Manchester United for a fee of close to £30m, making him the most expensive teenager in world football at that time. Since then he can't be blamed too much for his stuttering Red Devils' career.
Constant injuries, including a double leg fracture which kept him out of competitive football for almost a year, and falling out of favour with United manager Jose Mourinho has meant that Shaw's career in Manchester is still yet to really kick off. However, he is still only 22 and has time to get his career back on track.
6. Morgan Schneiderlin to Man Utd (2015)
Transfer fee: £25m
Morgan Schneiderlin had been on a journey with Southampton from League One to the Premier League. Finally making his name in the top flight, the Frenchman sealed a lucrative move to Manchester United for £25m.
But all did not work out for Schneiderlin at Manchester. Given a bit-part role at the club, the midfielder lasted just one full season for the Red Devils before getting fed up with his playing time. He is currently at Everton and still failing to have the same impact he had during his time with the Saints.
5. Calum Chambers to Arsenal (2014)
Transfer fee: £16m
Much like Luke Shaw, Calum Chambers' post-Southampton is yet to really kick off. Signing for Arsenal in 2014, Chambers has failed to land a regular role in Arsenal's defence and was shipped on loan to Middlesbrough for a season.
Still only 22, there is time for Chambers to finally make his mark with the Gunners, while some fans hold out hope that he can form a partnership with fellow youngster Rob Holding as the future of Arsenal's defence.
4. Nathaniel Clyne to Liverpool (2015)
Transfer fee: £12.5m
Nathaniel Clyne made his debut for Southampton in the Saints' first season back in the Premier League. After three steady seasons at St. Mary's, Clyne was snatched up by (you guessed it) Liverpool for £12.5m.
It today's market, Clyne represents a bargain for Liverpool. However, questions have been raised over his value as an attacking outlet in comparison with young contenders Trent Alexander-Arnold and Joe Gomez, while Clyne has yet to appear for Liverpool this season due to injury.
3. Adam Lallana to Liverpool (2014)
Transfer fee: £25m
Adam Lallana's summer move to Liverpool would have been particularly painful for Saints fans. The England international has been at the club for 14 years and he had represented the club in three different divisions.
After a season where he was included in the PFA Team of the Year, Liverpool paid a hefty £25m for Lallana. The midfielder's high work rate and pressing ability means he fits perfectly in Jurgen Klopp's style of football. A consistent player, Lallana continues to prove to be (when fit) a valuable man for the Reds.
2. Victor Wanyama to Tottenham Hotspur (2016)
Transfer fee: £11m
Victor Wanyama attracted a lot of interest in his playing days at Celtic. But it was Southampton who landed the Kenyan midfielder for £12.5m in July 2013. He would stay at the Saints for three seasons where he would consistently put in impressive performances in a holding midfield role.
Astonishingly, when Tottenham signed Wanyama in June 2016 they paid less than what Southampton initially paid for their star midfielder. Wanyama has gone on to be an important regular in Spurs' starting lineup. Tottenham's recent troubles have often been attributed to the fact that Wanyama has been injured since the start of this season.
1. Sadio Mane to Liverpool (2016)
Transfer fee: £34m
Sadio Mane made a short but immediate impact at the Saints. In his two seasons with the club, scoring 21 league goals.
In 2016, Liverpool signed Mane for £34m making him the most expensive African footballer in history at that time. He went on to be named Liverpool Player of the Year in his first season. Now, despite being outshone by teammates Mohamed Salah and Philippe Coutinho, he is a key part of Liverpool's formidable 'Fab Four' and one of the Premier League's most feared attackers.