Southampton travel to Old Trafford on Saturday to face Manchester United, knowing that a defeat for the Saints could see them potentially slip into the relegation zone.
Here is the best potential lineup for the match:
Englishman Fraser Forster is set to begin in goal. The ex-Celtic man has played in every minute of the Saints' 20 games this season, and is certainly a favourite of manager Mauricio Pellegrino.
The news of Virgil van Dijk's transfer will be music to the ears of many Southampton fans, as they look to offload their want-away star.
With the transfer of the Dutchman, the Saints will be hoping that they can keep a consistent back line for the coming months, which could possibly stabilise the ship and secure safety for next season.
Academy product James Ward-Prowse has not had the best of seasons so far. The Englishman has found game time hard to come by under Pellegrino, however he is set to start on Saturday, as Pellegrino will be looking to reshuffle his side following their 5-2 thrashing at the hands of Tottenham Hotspur last time out.
Irish international Shane Long proved to be very uninspiring against Tottenham Hotspur at the weekend, and therefore Manolo Gabbiadini is set to take the ex-Reading man's place up front.
Injury and suspension for Charlie Austin means that Gabbiadini is manager Pellegrino's only real option up front. The Italian began superbly in England, and this season has shown glimpses of his quality. The ex-Napoli man will be hoping to make an impact on the biggest stage come Saturday.