On his personal Instagram account Terry said, "I have just had news that I have broken my fifth metatarsal
"Devastated is an understatement to how I'm feeling tonight. I will be doing everything I can to get back fit as soon as possible."
Terry, who is 36-years old, had played every minute of Villa's 16 matches in the Championship this season thus far, following his summer arrival on a free transfer from Chelsea.
It was his 514th league game of a career in which he has made 739 club appearances and won 78 caps for England.
Speaking after his side's
"It looks like he'll be out for a while. But let's hope the injury is not so bad and that he will be out for six and not 12 weeks.
"It was an awful afternoon compounded by the loss of both John and Snoddy."
Villa lost the game 2-1, which was their first home defeat in the Championship this season, and now wait to find out how the full extent of time that they will be without the club captain, Terry.
Villa fell behind to an impressive Wednesday side after just 18 seconds through Adam Reach.
Jordan Rhodes then doubled the Wednesday's advantage, before Samba grabbed a last second consolation.
It leaves Bruce's side in fifth, nine points off league leaders Wolves, whilst Sheffield Wednesday saw their win move them up to 11th in the Championship.