Napoli are the only side in Europe with a 100% record in their domestic league. They've won all eight matches including an impressive away win at Roma on Saturday.
The only blot on their copybook was the matchday one loss in Ukraine against Shakhtar Donetsk.
Here is the side Maurizio Sarri could pick in Manchester.
Pepe Reina will continue in goal.
Napoli's defence is likely to be unchanged from the win at the Stadio Olimpico on Saturday. Raúl Albiol missed the last matchday against Feyenoord, but has recovered from his back injury. He will partner Kalidou Koulibaly at the heart of the defence.
Faouzi Ghoulam and Elseid Hysaj will provide the width.
Napoil's midfield is potentially the only thing that could change from the game at the weekend. Jorginho suffered a slight knock and could be replaced by Marko Rog.
Elsewhere, Napoli have two inform men in their midfield with the Brazilian Allan and Marek Hamšík, who hasn't missed a minute so far this season.
In order to counter City's free flowing attack, Napoli have a front three of their own bang in form. Between them, José Callejón, Dries Mertens and Lorenzo Insigne have scored 20 goals in 12 games in all competitions.
Insigne was the hero on Saturday as he netted the winner against Roma