Having progressed to the Champions League semi-finals after a 1-1 draw against Leicester City in midweek, Diego Simeone takes his side to Catalonia to face Espanyol.
Atlético are looking to make it 12 matches unbeaten in all competitions.
Jan Oblak will be between the sticks.
- Lucas Hernandez19
Atlético were successful in midweek at the King Power Stadium but it came at a huge cost defensively as both Filipe Luis and Juanfran picked up injuries that could see them out of action for a while.
Filipe Luis will also be a huge miss in an attacking sense as he has scored three goals in his last three La Liga games.
- Saúl 8
Saúl was the main man yet again for Atlético Madrid in the Champions League.
The 22-year-old Spaniard scored the crucial away goal in midweek to put his side in the driving seat for the remainder of the match and his goal in last year's Champions League semis against Bayern Munich also proved to be crucial in Atlético route to the final.
No player has been involved in more league goals for Atlético than Antoine Griezmann.
The Frenchman has had a stunning season as he has scored 15 La Liga goals and produced seven assists.
He's likely to be partnered with Fernando Torres this weekend as reserve striker Thomas didn't have the best of games last week as he missed a penalty against Osasuna.