Four second-half goals from Bayern Munich look to have condemned Arsenal to yet another Champions League last-16 exit as they slipped to a 5-1 defeat in their first-leg tie at the Allianz Arena.
Having matched the German champions for much of the opening 45 minutes, the Gunners were unable to deal with constant Bayern pressure after the break as goals from Arjen Robben, Robert Lewandowski, Thiago Alcantara and Thomas Muller appear to have left Alexis Sanchez's away goal surplus to requirements.
As expected, the hosts dominated the early possession and whilst Arsenal's tactic of sitting deep helped to stem the flow, it proved to be their undoing in only the 11th minute when Robben gave Bayern the lead in spectacular style.
The Dutchman was allowed to cut inside from the right and an in trademark style, sent a stunning 20-yard strike into the top left hand corner to give his side the perfect start.
The opening goal did little to alter the momentum of the game as Bayern continued to dominate the ball but with the Gunners appearing to have weathered the early storm, they equalised from nowhere just after the half-hour mark when Laurent Koscielny was fouled in the area by Lewandowski.
Sanchez took the subsequent spot-kick and though Manuel Neuer saved the striker's poor attempt, the Chilean was eventually able follow up at the time second time of asking and slot the ball into the bottom corner.
Keen to atone for giving away the penalty, Lewandowski headed over from close range minutes later as Munch looked to re-establish their lead and though Mats Hummels missed another close range header before half-time, the visitors went into the break worthy of the 1-1 scoreline as both Xhaka and Mesut Ozil wasted decent openings for Wenger's men.
The Gunners were dealt an early blow at the start of the second half when Koscielny had to be replaced by Gabriel Paulista through injury and the change in the away side's defence proved crucial as the north Londoners crumbled and conceded three goals in the space of 10 minutes.
The first came when Philip Lahm's deep cross from the right was brilliantly headed back past Ospina and into the corner by Lewandowski, who had done well to hold off Shkodran Mustafi and nod the ball towards goal whilst back-pedalling.
With their tails up, the hosts' quickly found their third of the night when Lewandowski turned provider as his neat flick put Thiago through on goal. With all the time in the world, the midfielder kept his composure to place the ball past the helpless Ospina to make it 3-1.
A rampant Bayern continued to poor forward and with Arsenal wilting under pressure, an inevitable fourth goal arrived in the 63rd minute, moments after the Bavarians had hit the bar.
A corner from the right caused havoc in the Gunners' penalty area and with the ball dropping to Thiago on the edge of the box, the Spaniard smashed an effort into the net, courtsey of a cruel deflection off of Xhaka.
With the match and tie seemingly over, the hosts started to take their foot off the gas, although they continued to pepper the Arsenal goal with shots and were denied by a number of smart saves by Ospina.
Perhaps fittingly, the night ended with a late Bayern goal when substitute Thomas Muller took advantage of sloppy play by the visitors to fire home from inside the area to round off the scoring and give Ancelotti's side a healthy advantage heading into the second-leg.
The 5-1 scoreline looks to have all but ended the tie, not to mention any hopes Arsenal had of making it through to the quarter-finals of the Champions League, and Wenger's team now look set to exit at the same stage of the competition for the seventh consecutive year.